View Hannah Maple’s profile on LinkedIn, the world's largest professional community. … Zayd Tippu. Patrick Carr. Both the temporal and spatial patterns of distant metastasis are highly variable in patients with RCC. All rights reserved. Zayd Tippu 2, Shuai Zhang 2, Sophie Merrick 2, Debra Josephs 2, Waqas Fazal 2, Sophie Papa 2, Nick Powell 1, 2, Nadia Yousaf 1, James Larkin 1, Martin Gore 1, Samra Turajlic 1; 1 Royal Marsden NHS Foundation Trust, London, UK; 2 Guys and St Thomas’ NHS Foundation Trust, London, UK Find the best way to get in touch with Zayd by joining Muck Rack. A total of 18,087 patients aged 18 years and older attended in that period, which was higher by … In 2015, she completed her training in medical oncology and became a consultant medical oncologist at the Royal Marsden, specialising in skin and urological cancers. Electronic address: ., Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Renal and Skin Units, The Royal Marsden … This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile. Tippu Z 1, Larkin JM 1, Carr A 2, Turajlic S 1. Immune checkpoint inhibitors (CPi) are a standard of care for various cancers however can cause unpredictable toxicity, notably of the lower gastrointestinal (GI) tract. 1 Royal Marsden NHS Zayd Tippu's 7 research works with 10 citations and 462 reads, including: Defining the true impact of coronavirus disease 2019 in the at-risk population of patients with cancer Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others. Neurological adverse events from immune checkpoint inhibition are increasingly recognised, especially with combination anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) and anti-programmed death receptor 1 (anti-PD-1) therapies. By Zayd Tippu, Kroopa Joshi, Downs Rd, Vasileios Angelis ejcancer.com — Highlights•Of patients who attended the Royal Marsden Hospital in Mar/Apr 2020, 113/13,489 (0.84%) were coronavirus disease 2019 (COVID-19) swab positive. However, improved T-cell proliferation may also lead to irAEs [1. The Virtual Health Library is a collection of scientific and technical information sources in health organized, and stored in electronic format in the countries of the Region of Latin America and the Caribbean, universally accessible on the Internet and compatible with international databases. nivolumab (nivo)) have improved outcomes in many cancers. Defining the true impact of coronavirus disease 2019 in the at-risk population of patients with cancer. Comparison of medication adherence and persistence in type 2 diabetes: A systematic review and meta‐analysis, Systematic review of adherence rates by medication class in type 2 diabetes: a study protocol. Here, we demonstrate representative sequencing (Rep-Seq) as a new method to achieve unbiased tumor tissue sampling. 1Lavinia Spain*, 2Amit Samani, 1,2Hajir Ibraheim, 1Lewis Au, 2Zayd Tippu, 2Shuai Zhang, 2 Sophie Merrick, 2 Debra Josephs, 2 Waqas Fazal, 2 Sophie Papa, 1,2 Nick Powell, 1 Nadia Yousaf, 1 James Larkin, 1 Martin Gore, 1 Samra Turajlic. apply the principles of representative sampling to implement an unbiased tumor sampling approach that improves the reproducibility and accuracy of … 4 authors ... Royal Marsden NHS Foundation Trust, London, UK. As continued expansion of their use is anticipated, we sought to investigate the ‘real world’ frequency and characteristics of such toxicity. Author information. This is caused by a tissue sample input of fixed dimensions (e.g., 6 mm biopsy), which becomes grossly under-powered as tumor volume scales. Zayd Tippu. As the population ages, many patients receiving such drugs will be older adults. Solid tumors are under-sampled in the clinic, such that only 0.0005% of initial tumor volume is used as input for diagnostic testing. Create a free Muck Rack account to customize your profile and upload a portfolio of your best work. There is a pressing need to characterise the nature, extent and duration of immune response to SARS-CoV-2 in cancer patients and inform risk-reduction strategies and preserve cancer outcomes. Алексей has 1 job listed on their profile. Molecular characterisation underpinning the diversity observed has been qualified, where the near ubiquitous loss of the short arm of chromosome 3 precedes distinct evolutionary trajectories involving different sequences and combinations of genetic events. Jennifer Thomas. Hang Xu. We evaluated 529 … Their presenting symptoms and signs are often subacute and highly variable, reflecting the numerous components of the nervous system. The Virtual Health Library is a collection of scientific and technical information sources in health organized, and stored in electronic format in the countries of the Region of Latin America and the Caribbean, universally accessible on the Internet and compatible with international databases. Litchfield et al. In cases #25 and #30, with native tumor tissues displaying a higher tumor mutational burden, a weaker correspondence between tumors and derived organoids was observed, likely ascribable to the procedures of tumor tissue sampling and organoid culture development. Royal Marsden Hospital. Such patients are under-represented in clinical trials, and therefore the safety of immune checkpoint inhibitors in this population has not been adequately assessed. Molecular characterisation underpinning the diversity observed has been qualified, where the near ubiquitous loss of the short arm of chromosome 3 precedes distinct evolutionary trajectories involving different seq... Background However their use is complicated by ICI-related diarrhoea/colitis (irD/C), a common cause of morbidity and ICI discontinuation. Robin Jones's 7 research works with 28 citations and 1,262 reads, including: Adaptive immunity to SARS-CoV-2 in cancer patients: The CAPTURE study Immune checkpoint inhibitors (ICIs) including anti-CLTA-4 (e.g. A retrospective multicenter analysi... Background Lewis Au, The Francis Crick Institute, Royal Marsden Hospital, London Samantha M. Hill, Roche Tissue Diagnostics, University of Arizona Zayd Tippu, Royal Marsden Hospital, London ipilimumab (ipi)) and anti-PD-1 antibodies (e.g. This result has various possible explanations, including different metastatic burden, different tumor biology, and tumor heterogeneity. Affiliations 1 Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. A diverse range of clinical phenotypes are observed in clear-cell renal cell carcinoma (ccRCC) with resultant therapeutic implications. Zayd Tippu Clinical Research Fellow at The Royal Marsden NHS Foundation Trust London. Zayd Tippu Clinical Research Fellow at The Royal Marsden NHS Foundation Trust. ; 2 Roche Tissue Diagnostics, 1910 E. Innovation Park Drive, Tucson, AZ 85755, USA. Royal Marsden Hospital. Francis Crick Institute - Cancer Evolution and Genome Instability Laboratory. ESMO Open 2019;4:e000540. … Total downloads of all papers by Zayd Tippu. At present, clinical practice often relies upon molecular information derived from a single biopsy of a primary or metastatic tumour. Semantic Scholar profile for S. McGrath, with 2 highly influential citations and 15 scientific research papers. The same tumour ( HCWs ) integrating longitudinal immune profiling and clinical annotation phenotypes observed... And clinical annotation of your best work Roche Tissue Diagnostics, 1910 E. 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